Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil

Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil

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Alkylglycerols (alkyl-Gro) are ether lipids abundant markbroyard.com in the liver of some elasmobranch fish species such as ratfishes and some sharks.Shark liver oil from Centrophorus squamosus (SLO), or alkyl-Gro mix from this source, have several in vivo biological activities including stimulation of hematopoiesis and immunological defences, sperm quality improvement, or anti-tumor and anti-metastasis activities.Several mechanisms are suggested for these multiple activities, resulting from incorporation of alkyl-Gro into membrane phospholipids, and lipid signaling interactions.Natural alkyl-Gro mix from SLO contains several alkyl-Gro, varying by chain length and unsaturation.Six prominent constituents of natural alkyl-Gro mix, namely 12:0, 14:0, 16:0, 18:0, 16:1 n-7, and 18:1 n-9 alkyl-Gro, were synthesized and tested for anti-tumor and anti-metastatic activities on a model echofix spring reverb of grafted tumor in mice (3LL cells).

16:1 and 18:1 alkyl-Gro showed strong activity in reducing lung metastasis number, while saturated alkyl-Gro had weaker (16:0) or no (12:0, 14:0, 18:0) effect.Multiple compounds and mechanisms are probably involved in the multiple activities of natural alkyl-Gro.